CMOS Circuits for Biomedical Applications

Constantine Sideris

Associate Professor of Electrical Engineering, Stanford University

Abstract: Over the past decade, biomedical device technologies have rapidly evolved, significantly transforming healthcare delivery and diagnostics. Complementary Metal-Oxide-Semiconductor (CMOS) integrated circuits, traditionally known as the cornerstone of digital computing, have emerged as a powerful platform driving advancements in biomedical devices. CMOS circuits provide unmatched capabilities, including high integration density, exceptional sensitivity, and cost-effective mass production, making them ideal for developing next-generation biomedical systems. In this presentation, I will discuss how the precise manipulation and detection of electric and magnetic fields enabled by CMOS technology can facilitate the creation of innovative, high-performance, and low-power biomedical devices. Highlighted examples, drawn from our recent research, will cover diverse applications such as magnetic biosensors for wash-free immunodetection at the Point-of-Care, magnetic localization techniques for ingestible “smart” pills, wireless wearable systems for motion tracking, high-voltage neural stimulation for optic nerve and deep brain stimulation with fully on-chip charge balancing, and the first pulse-mode Electron Paramagnetic Resonance (EPR) spectrometer integrated onto a single CMOS chip.

Bio: Constantine Sideris is an Associate Professor of Electrical Engineering at Stanford University. Previously, he was an Assistant Professor at the University of Southern California from 2018 to 2025 and an Associate Professor from 2025 to 2026. He received the B.S., M.S., and Ph.D. degrees with honors from the California Institute of Technology in 2010, 2011, and 2017 respectively. He was a visiting scholar at UC Berkeley’s Wireless Research Center from 2013 to 2014. He was a postdoctoral fellow in the departments of Electrical Engineering and Computing and Mathematical Sciences at Caltech from January 2017 to August 2018.

He was the recipient of an ONR YIP award in 2023, an NSF CAREER award in 2021, an AFOSR YIP award in 2020, an AFOSR DURIP award in 2021, the Caltech Leadership Award in 2017, and an NSF graduate research fellowship in 2010. His research is highly interdisciplinary and bridges the fields of bioengineering, medicine, applied mathematics and computation with electrical engineering and physics.

His research interests include analog/RF integrated circuits, photonic integrated circuits, and computational electromagnetics for biomedical and biosensing applications and wireless communications. His current interests in biomedical devices include portable Point-of-Care in-vitro biosensors, wearable devices for real-time monitoring and analysis of biological signals, ingestible “smart” pills, and implantable devices. His current interests in computational electromagnetics include developing fast algorithms for simulating RF and nanophotonic devices and coupling them with efficient optimization algorithms to achieve the automated design of new, high-performance electromagnetic devices.